Shortage of available organs for organ transplantation in end stage organ failure is a major challenge. Annually >10,00,000 patients die for the want of the functional organ. Demand of donating organ for the treatment of end stages organ failure has increased tremendously in recent years. The knowledge of stem cells has proved its potential for the treatment of various fatal diseases. Stem cells are known to regenerate injured tissues or to replace the lost cells in a very effective manner. Whole organ development requires not only the stem cells but also the contiguous stem cell niche or microenvironment and extracellular matrix with complete vasculature and integrity.