The safety of monosodium glutamate (MSG) usage as a food additive has generated much controversy locally and globally. The effect of MSG on the stomach of adult Wistar rat was investigated. Fifteen adult male Wistar rats of average weight of 175-200 grams were used in this study and randomly assigned into two treatments (n=6) and control (n=3) groups. The rats in the treatment groups received 3 and 6 gm/Kg body weight of MSG thorough oral route daily for seven days. The control rats received equal amounts of distilled water. The rats were sacrificed after seven days of the experiment. The stomach were carefully dissected out and quickly fixed in 10% formol saline for routine histological procedures.