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Alzheimer’s Disease (AD) is a progressive degenerative disease affecting the central nervous system, characterized by early memory impairments followed by cognitive deficit as aphasia, agnosia and apraxia. AD affects over 35 million individuals worldwide and is expected to affect 115 million by 2050. Cellular and molecular neurodegeneration detected in AD is characterized by synapse and neuronal loss, extracellular amyloid β (Aβ) peptide accumulation and intracellular neurofibrillary tangles (hyperphosphorylated tau). Less than 1% of AD cases are familiar, (onset before 60 to 65 years of age) due to mutations in three genes, APP, presenilin 1 (PSEN1), and presenilin 2 (PSEN2), all involved in Aβ overproduction.
Citation: Barbato C (2014) Alzheim(i)R: MicroRNAs in Alzheimer’s Disease. J Cytol Histol 5:e113
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