According to recent studies Subclinical hypothyroidism (SCH) may be independently associated with diabetic nephropathy in individuals with diabetes mellitus. Individuals with type 2 diabetes found no history of thyroid disease. Researchers evaluated the serum thyroid hormone levels and urinary albumin:creatinine ratio within the respective study. They characterized SCH as an elevated level of thyroid-stimulating hormone and diabetic nephropathy as Creatinine levels of 300 mg/g or even higher. The vogue of diabetic nephropathy was significantly higher in the SCH than the euthyroid group. On multivariate analysis, SCH was correlated with a 3.5 times increased bulge of diabetic nephropathy and a 4.6 times increased odds of hypertension, SCH was not exclusively associated with chronic kidney disease. These outcomes entail that SCH may be a new therapeutic target to prevent the advancement and progression of renal disease in diabetes individuals; thyroid function screening should be offered to diabetes patients with diabetic nephropathy.