Biocatalysts have been used in manufacturing food or fabrics for thousands of years. In the context of global concern about reducing chemical pollution and energy consumption, biocatalysis and biotransformation are of surging interest for both scientific and industrial researchers in the past few decades. As an environmentally benign process with higher efficiency and selectivity, enzyme-based catalysis is rapidly becoming a fresh paradigm for pharmaceutical, petrochemical, flavor and food industries. In the current third wave of biocatalysis, there have been numerous commercial enzymes with remarkable capabilities available for chemists. However, the pool of enzymes catering to industrial demands is still insufficient. Hence, it is still necessary to discover and engineer novel and better enzymes. Recently the trends in discovering and engineering enzymes for organic synthesis have been reviewed in depth .