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Estrogen Preferentially Acts on Visceral Afferents to Modulate the Nociception
Many illnesses affect women and men differently. Functional pain syndromes/disorders are more common in women, and some express themselves with different symptoms. With increased awareness of gender differences in responsiveness to therapies in such diseases as the irritable bowel syndrome (IBS) in gastroenterology; chronic pelvic pain (CPP) and endometriosis in gynecology; interstitial cystitis/painful bladder syndrome (IC/PBS) in urology; fibromyalgia in rheumatology; and others, there has been renewed interest in research of gynecologic factors and their possible relationship to visceral pain. Only a thorough understanding of the mechanism implicated in the development of these disorders can truly contribute to the designing of new and more efficient therapies
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