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The Effects of GLP-1 Receptor Agonists on Endothelial Function: Do They Function Directly or Indirectly?
Glucagon-like peptide 1 (GLP-1) receptor agonists, as well as dipeptidyl peptidase-4 inhibitors, have recently been widely used as therapeutics of type 2 diabetes [1]. According to the accumulation of clinical experience, cardiovascular protective effects of GLP-1 receptor agonists have been focused [2,3]. Although these effects may partly be due to their indirect glucose-lowering and weight-losing effects [4], recent evidence has indicated their direct effects on endothelium.
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