Cryogenic burns are therapeutic challenge to physicians in the absence any clear accepted management guidelines. We a patient is presented who was referred to National Burns Unit having sustained a full thickness burn after the application of a brand name sub-zero producing aerosol spray. These are recommended as a method of rapid analgesia for muscular strain which is the first reported case in the English literature. The direct exposure of skin to a liquid hydrocarbon gas may cause a severe freezing injury. However, burns secondary to the application of these extremely low temperature mediums are very rare. These injuries are mainly associated with an occupational exposure to agents which are known to represent a hazard, such as, liquid nitrogen or pressurized ammonia.