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Numerous clinical observations and epidemiological studies clearly indicate gender-specific variations in occurrence and severity of major common gender-neutral diseases with prominent socio-economical impact, such as colon cancer , obesity , multiple sclerosis, kidney, bone ], degenerative and cardiovascular disorders. Such gender-specific dimorphism observed in humans has been confirmed in experimental studies on animal models of some common human diseases. These clearly indicate that sex hormones may influence predisposition to and development of a wide range of common pathological condition.
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