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The endothelium is increasingly recognized as serving a critical role in maintaining circulatory homeostasis. Endothelial dysfunction is evidenced as an attenuation or exaggeration of the normal dynamic vasomotor range. Circulating endothelial progenitor cells (EPCs) are responsible for the endothelial replenishment. When EPC recruitment is insufficient after endothelial injury, endothelial pathophysiological ensues. Impaired endothelial function is associated with myriad cardiovascular diseases including coronary artery disease, atherosclerosis, hypertension, chronic heart failure, peripheral artery disease, diabetes, and chronic renal failure
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