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Pinning down the effects of individual foods in a varied diet is intrinsically difficult. The interaction of ingredients, cooking methods, other lifestyle factors and genetics leads to outcomes that are notoriously challenging to interpret. The macronutrients fat and carbohydrate and the mineral sodium have been blamed for obesity, type 2 diabetes and high blood pressure, all risk factors for cardiovascular disease, the number one cause of death in developed countries. Conversely, many nutritional studies have contradictory outcomes.