Meta Description: The hypothalamic neuropeptide “hypocretin-1” is also named orexin-A for its influence on food intake. An intracerebroventricular injection of hypocretin-1 does not merely affects food intake, but it also causes an increase in heart rate, blood pressure and metabolic rate.
The hypothalamic neuropeptide “hypocretin-1” is also named orexin-A for its influence on food intake. An intracerebroventricular injection of hypocretin-1 does not merely affects food intake, but it also causes an increase in heart rate, blood pressure and metabolic rate. These autonomic modifications indicate that this neuropeptide plays a role in the control of vegetative functions. Hypocretin-1 also affects thermoregulation, including changes in “core” temperature and temperature of interscapular brown adipose tissue.
The presence of hypocretin receptors in many cerebral areas indicates that several functions are played by hypocretin-1. Some antipsychotic drugs, as haloperidol, clozapine, risperidone, and quetiapine, modify the sympathetic and hyperthermic reactions due to hypocretin-1. A role for the hypocretin-1 in sleep regulation has been demonstrated. Deficiency in hypocretin-1 causes narcolepsy in mice, cats, dogs, and humans. Studies in rodents have indicated that hypocretin-1 crucial for the regulation of respiration.
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