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Development Translational Medicine in hepatitis C vaccine
Translational medicine has demonstrated first clinical trial of a hepatitis C vaccine in humans in safe and unprecedented immune responses, according to research. Antibodies are produced in B-cells that go after specific invaders. Hepatitis C virus constantly changes and has multiple genotypes which is challenging for scientists to get B-cells to work effectively in a hepatitis C vaccine.
T-cells are used instead of B-cells to target specific intruders, by this new vaccine provokes the immune system to go after the virus self-defense. Nearly 15-25 % of people who are infected with hepatitis C clear the virus spontaneously, according previous records. Researchers have found that a T-cell response plays a role in the ability of body to do so.
The researchers used chimpanzee viruses as vaccine vectors in the trial. The size and breadth of the immune responses are noted in the healthy volunteers which results as unprecedented in magnitude for a hepatitis C vaccine. Different T-cells are produced targeting different parts of the hepatitis C virus. Research is carried out, if it is able to prevent hepatitis C infection.
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