alexa Malignant melanoma

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Malignant melanoma

Malignant melanoma (MM) is a tumor that arises from the pigment producing cells (melanosomes) of the deeper layers of the skin (or the eye) and is the leading cause of death attributable to skin lesions. It is usually described as an irregular dark skin lesion that may have areas of varying colour. Although malignant melanoma metastasizes to several organs, endobronchial metastasis is rare. Furthermore, MM is generally known as a rapidly growing tumor, and recurrence are often observed within a short period. Thus, it is quite unusual for metastasis to be observed during a prolonged clinical course as seen in our case. Endobronchial metastases from non-pulmonary primary malignancies are rare, occurring in less than 2% of patients. The most frequent non-pulmonary primary tumors with endobronchial metastasis are breast, kidney and colon. When cutaneous melanoma disseminates, it has no preferential pattern of metastasis. In a review from 1962-2002, Sorensen, found a total of 204 patients with endobronchial metastases originating from 20 different primary extrapulmonary tumors. In this review, 8 of the cases were caused by metastatic melanoma.

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