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Single-molecule (SM) analytical techniques have proven capable of revealing elusive biomolecular interaction fundamentals critical to advancing our knowledge of complex cellular pathways, mechanisms of disease pathogenesis, and next-generation translational research in novel drug design. SM studies monitor the stochastic behavior of individual biomolecules under specific experimental conditions (e.g. temperature, salt concentration, enzyme substrates, analytes of interest, etc.) through the lens of a high-fidelity reporter (e.g. fluorescence). Read more...
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