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Growth factors and their receptors are members of the six broad groups of oncogene products that under finely tuned conditions play crucial biological roles in cell differentiation, organogenesis, development, tissues repair and apoptosis .These molecules have been conserved along the evolution and appear to be irreplaceable for the multiplicity and survival of metazoan organisms . It is likely that Stanley Cohen’s (Stanley Cohen-personal communication) was the first to exogenously administer a growth factor in pharmacological concentrations to an animal model, thus evoking an expected clinical response (corneal burns healing in rabbits). Since then, several growth factors have been scrutinized as candidates within the tissue repair scenario. With peaks and troughs EGF and PDGF opened up the first pharmacological attempts to improve the healing process and have evolved to stand as major players within the clinical armamentarium of hard-to-heal lower limb wounds.
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