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UGT2B17 was shown to be responsible for 32% of all ethanol glucuronidation. Tobacco and alcohol are major risk factors for upper aerodigestive tract (UADT) cancer, which includes head and neck cancer, and esophageal cancer, because these mucosal membranes are exposed directly to tobacco smoke and alcoholic drink. Multiple alcohol dehydrogenase gene polymorphisms were reported to associate with UADT cancer in the Japanese population. However, the effects of UGT2B17-deletion have not been studied, despite UGT2B17-deletion being highly prevalent in Japanese. Therefore, we aimed to examine the association between UGT2B17-deletion and UADT cancer as well as other types of cancers by conducting age- and gender-matched and nested case-control studies.
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