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Weissmann’s germ-soma distinction hypothesis includes the ageing-fertility trade-off concept along with the proposal of “Nothing makes sense in biology except in the light of evolution”. We postulate that life systems are spatiotemporally struggling for survival and broadly-defined immortality. Spatially, systems may try to occupy as much room as possible by producing more progeny and more cell growth and proliferation; temporally, they strive for as long a lifespan as possible. “Don’t put all eggs in one basket” means diversifying the options. While pursuing the long-term survival or immortality, the gonad or germline cells can emit the signal, an organism could thus need sacrifice its cell growth, cell proliferation or lifespan, this eventually makes ageing and cancer inevitable.
Citation: Zhang Y (2013) Ageing and Cancer: Breaking the “Dont Put All Eggs in One basket” and Natural “Self-organisation”, and their Potential Reprogramming via Modulation of Mi-2/NuRD, mTOR Kinase and Metabolism.
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