Alcohol hangover is a common phenomenon, experienced by numerous people amongst alcohol consuming societies. Recent research has demonstrated the impact of this phenomenon on various aspects such as quality of life, cognitive functioning and affect, work effectiveness and economy. Nevertheless, so far, no measure was found to be effective in reducing the burden of hangover, besides alcohol abstinence. While several strategies and products were systematically evaluated, none of them was found efficient. Two of the most purchasable drugs, alcohol and tobacco, are often co-abused. In fact, about 7% of the U.S. population is co-dependent. Additionally, alcoholism is estimated to be 10 times more common amongst smokers than nonsmokers. Concurrent use of these drugs poses significant public health concern and a large financial burden upon society.