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Hyperoxaluria leads to the formation of a particular kidney stone. Primary hyperoxaluria is a rare inherited disease caused by mutations in genes involved in the oxalate metabolism which leads to excessive endogenous oxalate synthesis resulting in increased plasma oxalate levels and hyperoxaluria.
The primary goal of hyperoxaluria management consists in the prevention of whewellite crystal formation/precipitation and ensuing kidney stone formation. Lanthanum carbonate (LC) emerged as an attractive drug for the management of uncontrolled hyperoxaluria, which is a calcium-free, non-resin based phosphate binder, which is prescribed for the management of hyperphosphatemia in patients with end-stage renal disease
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