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Cisplatin is a chemotherapy drug that is used to treat different types of cancer, and its chief dose-limiting side effect is nephrotoxicity, which evolves slowly and predictably after initial and repeated exposure. Organic cation transporter-2 is responsible for cisplatin uptake in the kidney. The use of antidepressant as a new approach for protective interventions of cisplatin-induced nephrotoxicity through the interference of cisplatin uptake by Organic Cation Transporter-2 to improve the therapeutic index of cisplatin and to treat depression which occurs in cancer patients together after considering the risk of side effects and interactions.
Studies still suggest research is needed to evaluate potential effect of antidepressants on CP-induced nephrotoxicity through interference of CP uptake by OCT2 to represent ideal renal protective compounds to improve the therapeutic index of CP and treat depression which occurs in cancer patients together after considering the risk of side effects and interactions.
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