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Meta Description: Diarrhea is the third leading cause of death related to infectious diseases all over the world, the rate of death due to diarrheal diseases is estimated as two million a year. All of the bacteria, parasites and viral pathogens are considered among the causes of infectious gastroenteritis. The wide diversity of bacterial and viral infections that may cause diarrhea complicates accurate surveillance and diagnosis, especially in developing countries.
Although the improvements in sanitation have significantly decreased the gastroenteritis cases caused by bacteria and parasites, it has little effect on viral gastroenteritis. The viruses causing gastroenteritis in humans include rotaviruses, caliciviruses (norovirus and sapovirus), astroviruses and enteric adenoviruses. Adenoviruses (Ad) were first isolated from civilians and army recruits who had respiratory disease.
Adenoviruses have linear double- stranded DNA genomes that generally range from 26 to 45 kb and are encapsulated in an icosahedra protein shell. Sequence analysis, has been demonstrated that the genomes of all human adenoviruses have similar genetic organization. Adenoviruses belonging to the Mastadenovirus genus in the family Adenoviridae cause a variety of diseases and are prevalent throughout the world.
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