Our Group organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.
PU.1 is a member of the Ezb transformation-specific sequence family of transcription factors and is expressed mainly in granulocytic, monocytic and B-lymphoid cells . The downregulation of PU.1 was reported to play a role in the pathogenesis of various hematological malignancies, including Acute Myeloid Leukemia (AML) , multiple myeloma and Myelodysplastic Syndrome (MDS) . PU.1 is also normally present in immature erythroid cells , and several reports have indicated that their downregulation is required for erythroid terminal differentiation .