alexa Opposing Role, Depending on the Stage, of PU.1 during Erythroid Differentiation

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Opposing Role, Depending on the Stage, of PU.1 during Erythroid Differentiation

PU.1 is a member of the Ezb transformation-specific sequence family of transcription factors and is expressed mainly in granulocytic, monocytic and B-lymphoid cells . The downregulation of PU.1 was reported to play a role in the pathogenesis of various hematological malignancies, including Acute Myeloid Leukemia (AML) , multiple myeloma and Myelodysplastic Syndrome (MDS) . PU.1 is also normally present in immature erythroid cells , and several reports have indicated that their downregulation is required for erythroid terminal differentiation .

 
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