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We report for the first time the Omphalitis infection in some neonates of the Niger Delta that was complicated with dipterous larval infections (myiasis) of their purulent umbilical cords. Unhygienic practices coupled with traditional ways of handling newborn babies and the application of non-sterile instruments during and after delivery at the rural settings promoted the aforementioned complications. Among 55 neonates examined for sepsis Omphalitis across the Niger Delta, 12 (21.8%) had dipterous larvae in their umbilical cords and stumps. The focus of the study was to assess the dermatological data of Omphalitis complicated with myiasis in newborns and establish the presence of other causes other than microorganisms in umbilical cords. Neonates of the age bracket (4-6 days old) showed higher infection rate with living larvae in decomposing umbilical cords