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Oral thrush or acute pseudomembranous candidiasis is a fungal infection of the oral mucosa with Candida albicans. Clinically, it appears as a white curd like plaque, which on removal leaves a red base. Oral thrush is an opportunistic infection of the oral cavity, which may be seen in newborn infants, the source of which may be from the birth canal, candidal infected skin of the mother’s nipple or a pacifier. Here a case of oral candidiasis is presented in an infant, who responded well to the treatment.