alexa A Novel Therapeutic Strategy against Prostate Cancer

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A Novel Therapeutic Strategy against Prostate Cancer

The expression and signaling of Androgen Receptor (AR) is necessary for the development of prostate cancer, and hence, is a major target for pharmaceutical drug development against the disease. AR, which is predominantly present in the cytoplasm when inactive, is activated by the binding of androgens resulting in its translocation to the nucleus. Once in the nucleus, AR modulates the expression of target genes by binding to androgen-responsive elements (ARE) on their promoter/enhancer regions and recruiting coregulators and other proteins of the transcriptional machinery..read more

 

 
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