Breast cancer is the second most frequent cancer in the world and is by far the most common malignant disease in women, with an incidence of 1.05 million new cases per year, accounting for 22% of all new cancer cases. It continues to be a major burden and cause of death among women worldwide. Breast cancer has been associated with a variety of risk factors both genetic and epigenetic. The Development of human breast cancer arises from various genetic alterations that drive the transformation of normal mammary epithelial cells into highly malignant derivatives. To encounter these alterations, breast cells have developed diverse pathways that are involved to repair different types of DNA damage and maintain genomic integrity. Several studies have reported that paucity in the DNA repair capacity may lead to deletions, amplifications, and/or mutations of critical genes that contribute to breast carcinogenesis. Online Journals are scholarly and peer reviewed journals. The journals provide forum and motivates scientists, researchers, academics, engineers, and practitioners in all aspects to share their professional and academic knowledge in the fields computing, engineering, humanities, economics, social sciences, management, medical science, and related disciplines. Online Journals also aims to reach a large number of readers worldwide with original and current research work completed on the vital issues of the above important disciplines. The journals permit all readers to read, view, download and print the full-text of all published articles without any subscription or restrictions.
Last date updated on June, 2014