Chromatin is subject to proofreading and repair mechanisms during the process of DNA replication, as well as repair to maintain genetic and epigenetic information and genome stability. The dynamic structure of chromatin modulates various nuclear processes, including transcription and replication, by altering the accessibility of the DNA to regulatory factors. Structural changes in chromatin are affected by the chemical modification of histone proteins and DNA, remodeling of nucleosomes, incorporation of variant histones, noncoding RNAs, and non-histone DNA binding proteins. Phenotypic diversity and fidelity can be balanced by controlling stochastic switching of chromatin structure and dynamics in response to the environmental disruptors and endogenous stresses. OMICS Group hosts over 700+ peer-reviewed journals and has organized over 3000+ International Scientific Conferences all over the world. OMICS International is has wide classification of journals and Molecular Biology is one of the important of them. Molecular Biology covers each and every aspect of gene studies from the very basic to the new advance.
Last date updated on November, 2020