Clinically-relevant colon cancer models are essential for further understanding of human colon cancer and developing new therapeutics for this public-health-threaten disease. The orthotopic transplantation model of human tumor has been demonstrated to be more patient-like animal tumor model. Orthotopic implantation of human tumor cells or tissue in the corresponding organ of nude mice resulted in some metastases. For colorectal cancer, human colon cancer cells or tissue implanted into the cecum of nude mice produce tumors which eventually metastasize to many organs including lymph node and live. However, observations of tumor growth, recurrence and metastasis are limited by the deep location of the colon.
Last date updated on June, 2014