For several decades, the phenomenon of drug resistance has remained the greatest challenge to malaria control, and it is part of the obstacles that sapped the dream of seeing malaria eradicated in the years 1970s. So far, resistance has been fully established in three of the five Plasmodium species responsible for human malaria (P. falciparum, P vivax and P. malariae). Cross resistance on the other hand is the simultaneous occurrence of resistance of the same parasite strain to two of more drugs belonging to the same drug family or exerting similar modes of action. Treatment failure is defined as âan inability to clear malarial parasitaemia or resolve clinical symptoms despite administration of an antimalarial medicineâ.
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Last date updated on July, 2014