|Obesity is generally recognized as an increasingly important cause of childhood and adolescent morbidity worldwide and is a contributor to chronic diseases such as type 2 diabetes mellitus (T2DM) and Coronary Heart Disease (CHD). Obesity has central role in Metabolic Syndrome (MetS). MetS has appeared with increasing frequency in children and adolescents, driven by the growing pediatric obesity epidemic. Behavioral factors such as poor dietary habits, a sedentary lifestyle, and a social environment which encourages unhealthy behaviors are closely correlated with the prevalence of obesity and MetS in adolescents]. MetS is characterized by a clustering of metabolic abnormalities which leads to increased cardiovascular disease and all-causes mortality. The five generally accepted features of metabolic syndrome are obesity, insulin resistance, dyslipidemia [including increased triglycerides and decreased HDL], impaired glucose tolerance, and hypertension. Recent studies suggest that MetS may be associated with subsequent risk of T2DM and CHD in young population, particularly in the overweight or obese. Considering recent global rise of childhood obesity prevalence, the overall prevalence of the metabolic syndrome in children and adolescents seems to be higher than what is estimated from previous studies.
Role of Ghrelin, Leptin and Insulin Resistance in Development of
Metabolic Syndrome in Obese Patients :Waleed S. Mohamed, Mohammed A. Hassanien and Khalid EL Sayed Abokhosheim