|Metabolic syndrome is the fastest growing health problem worldwide. Metabolic syndrome is a name given for a group of risk factors that collectively increase the risk for atherosclerotic cardiovascular disease (ASCVD), stroke, and type 2 diabetes. It is also known as syndrome X, the deadly quartet, and the insulin resistance syndrome. According to a recent estimate it affects one in five people in the United States and its incidence increases with advancing age. About 25% of the population of US suffers from metabolic syndrome. Two most important risk factors for metabolic syndrome are obesity and insulin resistance. As a result of insulin resistance sugar and fat levels rise in the affected individual. Other risk factors include genetics, fluctuating hormonal levels, and lack of physical activity. The most widely recognized of the metabolic risk factors are atherogenic dyslipidemia (AD), elevated blood pressure, and elevated plasma glucose. AD is characterized by three lipid abnormalities: elevated serum triglyceride, small low density lipoprotein (LDL) particles, and reduced high density lipoprotein (HDL) cholesterol levels. This lipid trinity is commonly seen in persons with premature coronary heart disease. Individuals with AD are obese, insulin resistant, and physically inactive.
Metabolic Syndrome: The Genetic Aspect: Vijaya Krishna Varanasi