|Individuals with certain rare single-gene disorders show group of abnormalities commonly seen in the metabolic syndrome. Studies indicate that development of metabolic syndrome is connected to common genetic variants, although the associations were weak and replications poor. It was suggested that thrifty genes, which maintain optimal levels of energy during periods of fasting, could be responsible for metabolic syndrome. Common variants in a number of candidate genes influencing fat and glucose metabolism together with various environmental factors can increase susceptibility to the syndrome. Among these, the genes for Î²3-adrenergic receptor, hormone-sensitive lipase, lipoprotein lipase, IRS-1, PC-1, skeletal muscle glycogen synthase, etc. appear to increase the risk of the metabolic syndrome. Candidate gene studies have identified linkage between metabolic syndrome and a number of genes, such as PPARÎ³, adiponectin, CD36, and Î² receptors. More research efforts are needed to establish the genetic basis of metabolic syndrome. Progress in understanding the genetic basis of metabolic syndrome should occur as soon as a consensus is reached on the true nature of metabolic syndrome, its components and diagnostic criteria.
Metabolic Syndrome: The Genetic Aspect: Vijaya Krishna Varanasi