The glucose metabolism is altered in the people with diabetes. In type 2 diabetes, the effectiveness of insulin is reduced and in type 1 diabetes, insulin levels in the body are low as the pancreatic beta cells stop producing insulin. Metabolic syndrome and type 2 diabetes, impairs the bodyâs ability to use glucose. As a result blood sugars levels increases, weight gain is more expected and the resistance to insulin becomes greater. Glucose production is increased in people with type 2 diabetes before and after food intake. Excessive glucose production occurs due to delayed insulin secretion and lack of suppression of glucagon release. Regulation of hepatic glucose metabolism in type 2 diabetes will require normalization of insulin and glucagon secretion as well as hepatic insulin action. In type 1 diabetes, the patients are administered with regular insulin for the glucose metabolism.
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Last date updated on May, 2021