|Protease constitute one of the primary targets in drug discovery. Many new ECP inhibitors are currently under clinical investigation and a significant increase in new therapies based on protease inhibition. Protease have evolved multiple times, and different classes of protease can perform same reactions by different catalytic mechanism. Protease can be found in animals, plants, bacteria, archea and viruses.
The impact factor of journal provides quantitative assessment tool for grading, evaluating, sorting and comparing journals of similar kind. It reflects the average number of citations to recent articles published in science and social science journals in a particular year or period, and is frequently used as a proxy for the relative importance of a journal within its field. It is first devised by Eugene Garfield, the founder of the Institute for Scientific Information. The impact factor of a journal is evaluated by dividing the number of current year citations to the source items published in that journal during the previous two years.