In the past few decades a large number of scientific papers, both computational and experimentalÂ in vitroÂ andÂ in vivo, have demonstrated that G-rich DNA sequences can fold as intrastrand quadruple helix structures called G-quadruplexes or G4-DNA. G4-DNA is stabilized by G-quartets, planar arrays of four guanines paired by Hoogsteen hydrogen bonding, and monovalent alkali cation, K+Â or Na+, located in the central cavity of the structure. In the human genome the sites that can potentially form G4- DNA are estimated to be more than 3,00,000. They are not randomly distributed, but located preferentially in repetitive genomic sequences such as the telomeres, ribosomal DNA and the immunoglobulin heavy-chain switch regions. OMICS Group through its Open Access Initiative is committed to make genuine and reliable contributions to the scientific community. OMICS Group hosts over 700+ peer-reviewed journals and has organized over 3000+ International Scientific Conferences all over the world. OMICS International is has wide classification of journals and Molecular Biology is one of the important of them. Molecular Biology covers each and every aspect of gene studies from the very basic to the new advance.
Last date updated on June, 2014