Screening for changes in gene expression across biological conditions using high throughput technologies is now common in biology. In this paper we present a broad Bayesian multilevel framework for developing computationally fast shrinkage-based screening tools for this purpose. Our scheme makes it easy to adapt the choice of statistics to the goals of the analysis and to the genomic distributions of signal and noise. We empirically investigate the extent to which these shrinkage-based statistics improve performance, and the situations in which such improvements are larger. Our evaluation uses both extensive simulations and controlled biological experiments. The experimental data include a socalled spike-in experiment, in which the target biological signal is known, and a two-sample experiment, which illustrates the typical conditions in which the methods are applied. Screening for Differentially Expressed Genes: Are Multilevel Models Helpful?: Dongmei Liu, Giovanni Parmigiani and Brian Caffo. Discovery and research are never ending process; man always tries to find something new for his advancement. Journals are the means of disseminating research findings. They help the common man to explore the discovery made by scholars. Journals play a very important role in maintaining periodical record of events and help us in collecting information and thus streamlining our knowledge. Generally, journals refer to collection of Scholarly articles that are published regularly and are peer reviewed. As its peer reviewed it enhances the collaborative efforts from scholars. Internationally published journals accelerate scientific research by increasing quality, competency and credibility. They increase the performance of each and every scholar there by contributing a lot to scientific community. Molecular Biology is one of the best reputed journals which publish original research, review, Short communication, Case study in the field of Molecular Biology.
Last date updated on July, 2014