Screening for changes in gene expression across biological conditions using high throughput technologies is now common in biology. In this paper we present a broad Bayesian multilevel framework for developing computationally fast shrinkage-based screening tools for this purpose. Our scheme makes it easy to adapt the choice of statistics to the goals of the analysis and to the genomic distributions of signal and noise. We empirically investigate the extent to which these shrinkage-based statistics improve performance, and the situations in which such improvements are larger. Our evaluation uses both extensive simulations and controlled biological experiments. Scholarly journals publish good quality articles by subjecting them to a thorough and careful peer review process. Articles are often anonymously reviewed by several other subject experts; this process is called "peer review process" and such a periodical is considered a "refereed journal. A scholarly journal presents rigorously peer-reviewed scientific articles in the following categories: original Research Articles, Communications, Reviews and Mini-Reviews, Commentaries and Letters to the Editor. OMICS Group International is one of the leading Open Access Publishers which is publishing 700+ peer-reviewed journals with the dramatic effort of editorial board members. Molecular Biology publishes original research articles, novel, and scientifically sound findings dealing with genes related living organism.
Last date updated on July, 2014