RNA has recently emerged as an important nanotechnology platform due to its extraordinary diversity in structure and function. Small interfering RNA (siRNA), showed significant potential in new molecular approaches to down-regulate specific gene expression in mammalian cells. In fact, targeted gene suppression by antisense DNA and siRNA has shown promising preclinical results, and/or is currently in clinical trials for a variety of diseases, including many forms of cancer (e.g., melanoma, neuroblastoma, and pancreatic adenocarcinoma), genetic disorders, and macular generation . Despite the high therapeutic potential of siRNA, its application for clinical medicine is still limited mainly due to the lack of appropriate delivery systems. In such a situation, the development of clinically suitable, safe, and effective drug-delivery biomaterials are required for the widespread use of siRNA therapeutics for disease treatment. Gene Silencing by siRNA Nanoparticles Synthesized via Sonochemical Method: Shimanovich U, Munder A, Loureiro A, Azoia NG, Gomes A, Cavaco-Paulo A, Gedanken A and Gruzman A. In the growing environment, they are many journals in various organisations. Only a very few journals maintain high standards in terms of the content they publish, one has to be careful while picking information as content that is not reliable and untrue can be harmful to research as well as society. Generally, journals can be rated by considering impact factor, reputation of authors, editorial board members and also in terms of the fee they charge. Only high indexing journals have quality articles. Molecular Biology is one of the best journals which publish quality articles.
Last date updated on July, 2014