Acute respiratory tract infections (ARTI) are the more frequent causes of morbidity and mortality in children. This review was conducted to assess the existing evidence concerning bacterial extracts efficacy in the prevention of pediatric ARTI. The data sources for the identification of clinical trials and reviews included principal bibliographic databases (MEDLINE, Embase, Cochrane Library, PubMed. Selected clinical trials only involved children suffering from recurrent ARTI. Bacterial extracts may reduce the incidence of ARTI of about 40% in toddlers (2-5 years), school boys (6-12 years) and children at higher ARTI risk (e.g. children living in orphanages). Among others, the active treatment with OM-85 led to 26, 2% fewer patients with recurrent ARTI. Data from the literature are encouraging, particularly for treatment with OM-85.
Peer review refers to the work done during the screening of submitted manuscripts and funding applications. This process encourages authors to meet the accepted standards of their discipline and reduces the dissemination of irrelevant findings, unwarranted claims, unacceptable interpretations, and personal views. Publications that have not undergone peer review are likely to be regarded with suspicion by academic scholars and professionals.
Last date updated on September, 2014