Hepatocellular carcinoma (HCC) is the most common primary liver neoplasm and the third leading cause of cancer deaths worldwide. Conventional therapies are not generally effective for advanced HCC and therefore a great effort is needed in developing approaches to prevent or reverse the progression of HCC. There is an emerging body of evidence that the peroxisome proliferator-activated nuclear receptors (PPAR) regulate the growth and proliferation of HCC cells. Herein, we provide a brief introduction to PPAR biology and review recent discoveries highlighting the importance of PPAR signaling in the modulation of hepatocellular carcinoma development.
The impact factor of journal provides quantitative assessment tool for grading, evaluating, sorting and comparing journals of similar kind. It reflects the average number of citations to recent articles published in science and social science journals in a particular year or period, and is frequently used as a proxy for the relative importance of a journal within its field. It is first devised by Eugene Garfield, the founder of the Institute for Scientific Information. The impact factor of a journal is evaluated by dividing the number of current year citations to the source items published in that journal during the previous two years.
Last date updated on June, 2014