Plasma or aggressive chemicals create reactive groups on PDMS that are highly unstable due to low glass transition temperature of -120Â°C, but allow for further covalent immobilization of proteins. Demonstrated this approach by covalently immobilizing RGD peptides onto PDMS, which resulted in adequate attachment of A427 cells (a colon cancer cell line). Feinberg employed this approach to immobilize fibronectin in a microprinted dot array onto PDMS that supported an endothelial layer of an exceptionally high density for a culture period of up to 18 days.
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Last date updated on July, 2014