Immobilization

Plasma or aggressive chemicals create reactive groups on PDMS that are highly unstable due to low glass transition temperature of -120°C, but allow for further covalent immobilization of proteins. Demonstrated this approach by covalently immobilizing RGD peptides onto PDMS, which resulted in adequate attachment of A427 cells (a colon cancer cell line). Feinberg employed this approach to immobilize fibronectin in a microprinted dot array onto PDMS that supported an endothelial layer of an exceptionally high density for a culture period of up to 18 days. OMICS Group International is one of the leading Open Access Publishers which is publishing 700+ peer-reviewed journals with the support of 50,000+ editorial board members as editorial team and aimed to disseminate the scholarly knowledge to the scientific society. OMICS Group also organizing 3000+ International Scientific Conferences and events yearly all over the world with the support of 1000+ Scientific associations worldwide.

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Last date updated on April, 2024