Breast cancer is the most common form of cancer among women, comprising approximately 23% of all tumors in women. Although mortality has been decreasing in some countries, breast cancer is still the most frequent cause of death among women between ages 35 and 55. The broad understanding of risk factors for breast cancer results in better insight of biomolecular processes leading to the disease, allowing for health professionals to offer information, counseling, and objective answers to emerging patient questions. In terms of public health, the recognition of risk factors for a pathology and its adequate management towards tracing, treatment, and prevention are of essential importance in order to lower its incidence and, therefore, its prevalence. The study of polymorphisms related to the disease are tools that may have direct implications of great importance in the individual susceptibility to breast cancer on the study of response to several drugs, as well as prognostics. This study was motivated by a study of polymorphisms in lowly-penetrant genes previously associated to increased breast cancer risk and high mammographic density in post-menopause women.
Last date updated on June, 2014