MicroRNAs (miRNAs) were originally identified in 1993, when a non-coding small RNA gene, lin-4, has been discovered in a genetic screen utilized to find out genes controlling developmental timing of the nematode, Caenorhabditis elegans larvae. Findings about lin-4 and other newly discovered small non-coding RNAs having the capacity to alter gene expression post-transcriptionally in a variety of species including mammalians, put forward miRNAs, which, are endogenously synthesized, approximately 22 nucleotide-long, single stranded and non-coding RNAs, as indispensable components of noncoding genome
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Last date updated on July, 2014