Lung transplantations associated risks such as acute and chronic graft rejection, the need for life-long immunosuppression and a five year survival rate of just above 50% lead to its classification as a treatment of last resort. In addition, the development of obstructive bronchiolitis over time is a major problem in these patients. Leading to transplantation early in life, Mucoviscidosis is the most frequent inborn cause of terminal chronic respiratory insufficiency with an incidence of 1 in 3000 live-births.
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Last date updated on July, 2014