Multiple Myeloma (MM) is a progressive and debilitating B-cell disorder typified by the accumulation and dissemination of malignant plasma cells in the bone marrow which subsequently induce osteolytic lesions. Despite recent advancement of new therapies for MM, patients ultimately develop drug resistance and succumb to the disease. This highlights the need to increase our understanding of the disease and to identify new myeloma targets for drug development. The growth and progression of myeloma is multifaceted and signaling through several cytokine/receptor pathways have been shown to be vital for the pathobiology of this disease. Evidence for the MET receptor signaling pathway being an important contributor to the pathogenesis of this disease has been mounting. Both MET and its ligand, hepatocyte growth factor (HGF), are expressed in an autocrine loop in most myeloma cell lines and primary patient samples, as discerned at both the mRNA.Review articles are the summary of current state of understanding on a particular research topic. They analyze or discuss research previously published by scientist and academicians rather than reporting novel research results.
Review article comes in the form of systematic reviews and literature reviews and are a form of secondary literature. Systematic reviews determine an objective list of criteria, and find all previously published original research papers that meet the criteria. They then compare the results presented in these papers. Literature reviews, by contrast, provide a summary of what the authors believe are the best and most relevant prior publications.
The concept of "review article" is separate from the concept of peer-reviewed literature. It is possible for a review to be peer-reviewed, and it is possible for a review to be non-peer-reviewed.
Last date updated on June, 2014