The antidiuretic hormone vasopressin regulates water reabsorption in the nephron by inducing apical plasma membrane exocytosis of the water channel aquaporin 2 in the kidney collecting duct principal cells. Water inside and outside the cells represent approximately 60% of total human body weight. The maintenance of fluids homeostasis is essential for most physiological processes. For this reason, urinary excretion of water is finely regulated to allow a rapid adaptation to water uptakes and losses and maintain constant salt concentration in intra-and extracellular fluids.
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Last date updated on November, 2020