Kidney involvement is one of the most important clinical features of systemic lupus erythematosus (SLE).Therefore, histopathological analysis of renal sections is necessary to evaluate the magnitude of lupus-like diseases. However, histopathological grading requires advanced pathological skills; otherwise the subjective views of the investigator can enter into evaluation. Here we show that in the case of a BXSB lupus mouse strain, the area and the long axis of glomeruli can be used as an objective index that can aid in the evaluation of the severity of lupus glomerulonephritis. The magnitude of glomerulonephritis is graded according to the intensity and extent of renal lesions. However, this grading requires advanced pathologic skills of more than two pathologists, otherwise the biases of the investigators can enter into evaluation. Moreover, the histopathological character of glomerulonephritis in SLE is occasionally that of cell proliferation dominance, or otherwise conspicuous immune deposits. Emiko Takeuchi, Convenient Evaluation of Magnitude of Glomerulonephritis in BXSB/Mp Lupus Mice. A journal is a periodical publication intended to further progress of science, usually by reporting new research. Most journals are highly specialized, although some of the oldest journals publish articles, reviews, editorials, short communications, letters, and scientific papers across a wide range of scientific fields. Journals contain articles that peer reviewed, in an attempt to ensure that articles meet the journal's standards of quality, and scientific validity. Each such journal article becomes part of the permanent scientific record.
Last date updated on June, 2014