Hepatocellular carcinoma (HCC) is a common solid tumor. At present, the only curative treatment options for HCC are liver resection and liver transplantation (LT).However, recurrent HCC after LT remains one of the major problems in overcoming this disease. Specifically, the rate of HCC recurrence after LT is approximately 10-30% . Surgical resection is the treatment of choice for local recurrence, but this approach is often not possible in many cases due to extrahepatic tumor dissemination. Furthermore, conventional cytotoxic chemotherapy exhibits low efficacy.Open access to the scientific literature means the removal of barriers (including price barriers) from accessing scholarly work. There are two parallel roads towards open access: Open Access articles and self-archiving. Open Access articles are immediately, freely available on their Web site, a model mostly funded by charges paid by the author (usually through a research grant). The alternative for a researcher is self-archiving (i.e., to publish in a traditional journal, where only subscribers have immediate access, but to make the article available on their personal and/or institutional Web sites (including so-called repositories or archives)), which is a practice allowed by many scholarly journals.
Open Access raises practical and policy questions for scholars, publishers, funders, and policymakers alike, including what the return on investment is when paying an article processing fee to publish in an Open Access articles, or whether investments into institutional repositories should be made and whether self-archiving should be made mandatory, as contemplated by some funders.
Last date updated on June, 2014