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Post-exposure prophylaxis or Post-exposure prevention (PEP) is any preventive medical treatment started immediately after exposure to a pathogen (such as a disease-causing virus), in order to prevent infection by the pathogen and the development of disease.
Post-exposure prophylaxis (PEP) guidelines lack a substantive evidence base to guide advice. It is extremely unlikely that this will change, as randomised studies of different drug regimens for PEP are not feasible owing to the complexity of exposure, low event rate, and inability to ethically have a placebo group. Evolving basic science understanding, along with further studies on animals and prevention of mother-to-child transmission (PMTCT) findings, will continue to guide policy makers.